What Is VDR?
VDR is a gene that encodes a vitamin-D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene, the rs2228570 (FokI polymorphism), is associated with decreased bone mineral density in white prepubertal girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is regulated through the reciprocal pattern as well as the temporal off-and-on occupancy of the VDRE between the two components. It is also controlled by chromosomal locations and binding preferences for specific hormones. Microarray studies in human cells show that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) is an archive of data and documents relevant to business, legal transactions or processes. Viewing, downloading, or printing are not permitted. It utilizes a central computer and an extranet, which is a restricted-access Internet connection that allows users to log on at specific times.
VDRs are most commonly used by investment banks and businesses involved in mergers and acquisitions. They require to communicate information in a clear way with potential investors or buyers. Due diligence processes will also require a significant amount of data. Life science companies also utilize VDRs to keep everything from clinical trial results to HIPAA documentation.
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